Phenanthrenes and derivatives
Apexbio Technology LLC Oxaloacetic acid 328-42-7 200mg
Oxaloacetic acid (CAS 328-42-7) is a small molecule metabolic intermediate involved in multiple biosynthetic pathways including the citric acid cycle It modulates mitochondrial metabolism and has been shown to reduce intracellular reactive oxygen species (ROS) levels thereby attenuating oxidative stress in cells Due to these properties oxaloacetic acid serves as a valuable tool in the investigation of metabolic disorders and mitochondrial dysfunction in biomedical research
Medchemexpress LLC PROTAC BCR-ABL Degrader-1 | C43H40N10O6 | 25 MG
PROTAC BCR-ABL Degrader-1 (compound PROTAC 1) is a PROTAC with a 2-oxoethyl linker. It induces Bcr-Abl degradation in a ubiquitinproteasome-dependent manner and exhibits antiproliferative activity against K562 cells. It has the potential to study cancer.
- Induces Bcr-Abl degradation.
- Exhibits antiproliferative activity against K562 cells.
- Useful for cancer research.
- Features a 2-oxoethyl linker.
eMolecules Chem-Impex Malonic acid anhydrous 5kg 272385282 02873 0 000 141-82-2 104 061 C3H4O4
Chem-Impex Malonic acid anhydrous 5kg 272385282 02873 0 000 141-82-2 104 061 C3H4O4
Medchemexpress LLC Sch-1473759 hydrochloride | 1094067-13-6 | MFCD18251447 | 99.2% | 463.00 g/mol | C20H27ClN8OS | 200 MG
SCH-1473759 hydrochloride is a small-molecule dual aurora kinase inhibitor used in research to probe cell-cycle regulation and kinase signaling. It potently inhibits Aurora A and Aurora B at low nanomolar concentrations and displays activity against several related kinases.
- Potent dual Aurora A and B inhibition (IC50 = 4 nM and 13 nM).
- Direct binding to Aurora kinases (Kd ≈ 20-30 nM).
- Additional kinase activity including VEGFR2, Src family, Chk1, and IRAK4.
- High purity (≈99.2%) and solid, white to yellow physical form.
- Soluble in DMSO and water with warming; reported in vivo formulation options available.
- Suitable for cell-cycle and kinase signaling research applications.
- Recommended sealed storage; in solvent long-term storage at -80°C.
Selleck Chemical LLC Malonic acid S3029-1g
Malonic acid (MOA) one of the major dicarboxylic acids (DCAs) in aerosols has been identified experimentally and computationally to be a strong acid Malonic acid (MOA) acts as a mediate bridge for the formation of pure SA-A-based clusters
eMolecules Key Organics/BIONET Malonic acid 1mg 564178357 STR00614 95 000 141-82-2 104 061 C3H4O4
Key Organics/BIONET Malonic acid 1mg 564178357 STR00614 95 000 141-82-2 104 061 C3H4O4
Medchemexpress LLC Alvespimycin (hydrochloride) | 467214-21-7 | 98.8% | 653.21 | 200 MG
Alvespimycin hydrochloride is a potent inhibitor of Hsp90, binding to Hsp90 with an EC50 of 62 ± 29 nM. It inhibits the growth of human cancer cell lines SKBR3 and SKOV3, which overexpress Hsp90 client protein Her2, leading to down-regulation of Her2 and induction of Hsp70. It also induces dose-dependent apoptosis in chronic lymphocytic leukemia (CLL) cells.
- Potent inhibitor of Hsp90
- Binds to Hsp90 with an EC50 of 62 ± 29 nM
- Inhibits the growth of human cancer cell lines SKBR3 and SKOV3
- Causes down-regulation of Her2
- Induces Hsp70
- Induces dose-dependent apoptosis in chronic lymphocytic leukemia (CLL) cells
- Significant reduction in tumor size in animal models