Phenanthrenes and derivatives
Medchemexpress LLC Piperidolate hydrochloride | 129-77-1 | 99.66% | 200 MG
Piperidolate hydrochloride is an antimuscarinic agent that inhibits intestinal cramps induced by acetylcholine in rats and dogs. This compound is intended for research use only.
- Antimuscarinic agent
- Inhibits intestinal cramps
- Research use only
- White to off-white solid appearance
Medchemexpress LLC PROTAC BCR-ABL Degrader-1 | C43H40N10O6 | 25 MG
PROTAC BCR-ABL Degrader-1 (compound PROTAC 1) is a PROTAC with a 2-oxoethyl linker. It induces Bcr-Abl degradation in a ubiquitinproteasome-dependent manner and exhibits antiproliferative activity against K562 cells. It has the potential to study cancer.
- Induces Bcr-Abl degradation.
- Exhibits antiproliferative activity against K562 cells.
- Useful for cancer research.
- Features a 2-oxoethyl linker.
Medchemexpress LLC Gabapentin hydrochloride | 60142-95-2 | >98.0% | C9H18ClNO2 | 200 MG
Gabapentin hydrochloride is a potent, orally active P/Q type Ca2+ channel blocker. It functions by inhibiting neuronal Ca2+ influx and reducing neurotransmitter release. This compound, which is a GABA analog, can be used to relieve neuropathic pain.
- It is a potent calcium channel blocker.
- It is orally active.
- Inhibits neuronal calcium influx.
- Reduces neurotransmitter release.
- It is a GABA analog.
- Can be used to relieve neuropathic pain.
eMolecules 2230820-11-6 | AZD-7648 | TargetMol US380.412 | C18H20N8O2 | 0.000 | Cc1cc2ncnn2cc1Nc1ncc2n(C)c(=O)n(C3CCOCC3)c2n1 | 200mg | 894473472
AZD-7648 | TargetMol US | 2230820-11-6380.412 | C18H20N8O2 | 0.000 | Cc1cc2ncnn2cc1Nc1ncc2n(C)c(=O)n(C3CCOCC3)c2n1 | 200mg | 894473472
Sigma Aldrich Fine Chemicals Biosciences Triphenylene BCR(R), certified reference material | 217-59-4 | MFCD00001108 | 20MG
Triphenylene BCR(R), certified reference material | Mol Wt: 228.29 | 217-59-4 | MFCD00001108 | 20MG
Medchemexpress LLC Alvespimycin (hydrochloride) | 467214-21-7 | 98.8% | 653.21 | 200 MG
Alvespimycin hydrochloride is a potent inhibitor of Hsp90, binding to Hsp90 with an EC50 of 62 ± 29 nM. It inhibits the growth of human cancer cell lines SKBR3 and SKOV3, which overexpress Hsp90 client protein Her2, leading to down-regulation of Her2 and induction of Hsp70. It also induces dose-dependent apoptosis in chronic lymphocytic leukemia (CLL) cells.
- Potent inhibitor of Hsp90
- Binds to Hsp90 with an EC50 of 62 ± 29 nM
- Inhibits the growth of human cancer cell lines SKBR3 and SKOV3
- Causes down-regulation of Her2
- Induces Hsp70
- Induces dose-dependent apoptosis in chronic lymphocytic leukemia (CLL) cells
- Significant reduction in tumor size in animal models
Medchemexpress LLC Fullerene-C60-Ih (9CI, ACI) | 99685-96-8 | MFCD00151408 | 99.7% | 720.64 g·mol⁻¹ | C60 | 100 MG
Fullerene-C60 (C60) is a high-purity carbon nanomaterial (buckminsterfullerene) used in photophysical and biochemical research. It serves as an effective electron acceptor and radical scavenger, and efficiently produces singlet oxygen upon light excitation, making it useful for photodynamic studies and electron-transfer experiments.
- High purity suitable for laboratory research.
- Efficient singlet oxygen generation under UV/visible light.
- Strong electron-accepting and radical-scavenging properties.
- Available in small pack sizes for experimental flexibility.
- Well-characterized molecular weight and composition.
Medchemexpress LLC Irinotecan hydrochloride trihydrate | 136572-09-3 | 99.9% | 200 MG
Irinotecan hydrochloride trihydrate is a potent topoisomerase I inhibitor known for its antitumor activity. It targets Topoisomerase I, playing a crucial role in cancer research and drug development.
- Inhibits the growth of LoVo and HT-29 cells.
- Suppresses the proliferation of human umbilical vein endothelial cells (HUVEC).
- Significantly inhibits tumor growth in various in vivo models.
- Shows effectiveness against HT-29 xenografts.
Apexbio Technology LLC Tricosanoic acid 2433-96-7 200mg
Tricosanoic acid (CAS 2433-96-7) is a saturated long-chain fatty acid comprising 23 carbon atoms naturally present in plant oils animal fats and waxes While its precise molecular targets remain to be fully elucidated tricosanoic acid serves as a model compound in studies examining lipid metabolism membrane biophysics and the structural effects of very long-chain saturated fatty acids within biological membranes It is utilized in research exploring fatty acid incorporation lipid signaling pathways and the biophysical properties of lipid bilayers Its applications extend to investigations in metabolic disorders lipidomics and membrane dynamics
Medchemexpress LLC Cetirizine (dihydrochloride) | 83881-52-1 | 99.6% | 461.81 | 200 MG
Cetirizine dihydrochloride, a second-generation antihistamine and the carboxylated metabolite of hydroxyzine, is a specific, orally active and long-acting histamine H1-receptor antagonist. It marks antiallergic properties and inhibits eosinophil chemotaxis during the allergic response.
- Second-generation antihistamine
- Carboxylated metabolite of hydroxyzine
- Specific, orally active, and long-acting histamine H1-receptor antagonist
- Marks antiallergic properties
- Inhibits eosinophil chemotaxis during the allergic response
Medchemexpress LLC Sch-1473759 hydrochloride | 1094067-13-6 | MFCD18251447 | 99.2% | 463.00 g/mol | C20H27ClN8OS | 200 MG
SCH-1473759 hydrochloride is a small-molecule dual aurora kinase inhibitor used in research to probe cell-cycle regulation and kinase signaling. It potently inhibits Aurora A and Aurora B at low nanomolar concentrations and displays activity against several related kinases.
- Potent dual Aurora A and B inhibition (IC50 = 4 nM and 13 nM).
- Direct binding to Aurora kinases (Kd ≈ 20-30 nM).
- Additional kinase activity including VEGFR2, Src family, Chk1, and IRAK4.
- High purity (≈99.2%) and solid, white to yellow physical form.
- Soluble in DMSO and water with warming; reported in vivo formulation options available.
- Suitable for cell-cycle and kinase signaling research applications.
- Recommended sealed storage; in solvent long-term storage at -80°C.
Apexbio Technology LLC Sinapinic acid 530-59-6 200mg
Sinapinic acid (CAS 530-59-6) is an organic compound commonly utilized as a matrix in matrix-assisted laser desorption/ionization (MALDI) mass spectrometry where it facilitates the desorption and ionization of proteins and peptides for accurate molecular weight determination The compound s ability to absorb laser energy and promote analyte ionization underpins its effectiveness in proteomics research Additionally sinapinic acid is naturally occurring in propolis contributing to the compound s significance in natural product studies Its primary research applications center on biomolecular analysis and the characterization of protein mixtures
Medchemexpress LLC AM095 free acid | 1228690-36-5 | 99.0% | 456.49 | 200 MG
AM095 free acid is a potent LPA1 receptor antagonist that effectively inhibits LPA-induced calcium flux in CHO cells transfected with human or mouse LPA1. It also significantly reduces LPA-induced vasorelaxation and inhibits LPA-driven chemotaxis in various cell types. In preclinical studies, it has shown to attenuate bleomycin-induced dermal fibrosis and decrease kidney fibrosis in a mouse model of unilateral ureteral obstruction. The compound exhibits high oral bioavailability, a moderate half-life, and is well tolerated in animal models.
- Potent LPA1 receptor antagonist.
- Inhibits LPA-induced calcium flux in CHO cells.
- Reduces LPA-induced vasorelaxation.
- Inhibits LPA-driven chemotaxis in melanoma cells.
- Attenuates bleomycin-induced dermal fibrosis in vivo.
- Decreases kidney fibrosis in a mouse model.
- High oral bioavailability.
- Moderate half-life.
- Well tolerated in rats and dogs.
eMolecules 141-82-2 | Malonic acid anhydrous | Chem-Impex104.061 | C3H4O4 | 99.000 | OC(=O)CC(O)=O | 10kg | 112444175
Malonic acid anhydrous | Chem-Impex | 141-82-2104.061 | C3H4O4 | 99.000 | OC(=O)CC(O)=O | 10kg | 112444175
Apexbio Technology LLC Alendronic acid 66376-36-1 200mg
Alendronic acid is a small-molecule inhibitor targeting farnesyl diphosphate synthase (FDPS) It is designed to inhibit FDPS activity thereby disrupting protein prenylation pathways required for osteoclast functionality and regulating osteoclast-mediated bone resorption Alendronic acid exerts its biological activity primarily through inhibition of FDPS which suppresses osteoclast activity and associated bone mineral degradation Based on these pharmacological properties alendronic acid holds research potential in the investigation of bone remodeling mechanisms particularly in the contexts of postmenopausal osteoporosis Paget s disease and tumor-related hypercalcemia